Peripheral versus central potencies of N-type voltage-sensitive calcium channel blockers.
Sympatholysis after neuron-specific, N-type, voltage-sensitive calcium channel blockade: first demonstration of N-channel function in humans.
Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats.
Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain.
Pharmacokinetics of SNX-111, a selective N-type calcium channel blocker, in rats and cynomolgus monkeys.
Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.
Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures.
Time-course and treatment response with SNX-111, an N-type calcium channel blocker, in a rodent model of focal cerebral ischemia using diffusion-weighted MRI.
Antagonists of neuronal calcium channels: structure, function, and therapeutic implications.
Contribution of L- and non-L-type calcium channels to voltage-gated calcium current and glucose-dependent insulin secretion in HIT-T15 cells.
Determination of disulfide bridge pattern in omega-conopeptides.
Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA.
Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy.
Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats.
A selective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia.
Characteristics of a human N-type calcium channel expressed in HEK293 cells.
Structure-activity analysis of a Conus peptide blocker of N-type neuronal calcium channels
Effects of omega-toxins on noradrenergic neurotransmission in beating guinea pig atria.
Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel omega-conopeptides and omega-agatoxin-IVA.
Irreversible and reversible blockade of IMR32 calcium channel currents by synthetic MVIIA and iodinated MVIIC omega-conopeptides.
A novel omega-conopeptide for the presynaptic localization of calcium channels at the mammalian neuromuscular junction.
Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats.
A selective N-type Ca(2+)-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia.
Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (omega-conopeptide MVIIC).
Calcium channel antagonist peptides define several components of transmitter release in the hippocampus.
Characterization of the binding of omega-conopeptides to different classes of non-L-type neuronal calcium channels.
Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia.
Synthesis of disulfide-bridged fragments of omega-conotoxins GVIA and MVIIA. Use of Npys as a protecting/activating group for cysteine in Fmoc syntheses.
Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids.
Diversity of Conus neuropeptides.
Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes.
Novel omega-conopeptides reduced field potential amplitudes in the rat hippocampal slice.
Administration of an omega-conopeptide one hour following traumatic brain injury reduces 45calcium accumulation.
Pharmacological characterisation of the calcium channels coupled to the plateau phase of KCl-induced intracellular free Ca2+ elevation in chicken and rat synaptosomes.
Localization of [125I]omega-conotoxin GVIA binding in human hippocampus and cerebellum.
A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia.
Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis.
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.
Novel alpha- and omega-conotoxins from Conus striatus venom.
Ziconotide
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